We're in Corvallis with a 262 conversion, dual 75 amp alternators, TKS. Without Monroy tanks Palm Springs from PDX non stop will be tight. Probably a 5 hour flight in the high teens in mine. I cruise at 65% ROP. Haven't managed to get mine to run smooth while lean. We make that trip at least once a year and up high down the east side will pencil out, but there are no small number of days when running down the east side of the sierras will be unpleasant. We usually stick to the valley to Palmdale and then cut east. Costs some time but usually a better ride with better outs.
We trek to Santa Barbara a few times a year, that would be no problem with standard tanks non-stop.
Most of my flying is for work around the northwest. The airplane has proven to be truly capable.
Rockets are faster, but every time I sit down and compare the travel times, you burn more gas to save a few minutes. Even PSP from CVO the extra 25 knots only yields a half-hour saved.