I've been flying to my project sites for years and now do it in a 262 conversion, so I've got some direct experience. Can be a huge time saver and definitely a frustration reducer and increases the number of nights in my own bed. Did it in an E for many years in the Northwest crossing mountains. The plane didn't have the capability to give me super dispatch reliability, but if you need to go, you drive or fly the tube. The combination of ice and MEAs in my neighborhood often limited options for the E.
I would not do my instrument or commercial in a 252. I did both in my E and that was no problem. As a practical matter, you spend too much time flying the engine instruments in a turbo and it would distract from learning instrument flying. Same for the commercial.
Before I spent the money on a 252, I'd want some sort of guarantee from my employer that this was and will continue to be allowed. The next CFO could pull the rug out from under this in a heartbeat. Say airplane and people get weird. I say it because it has happened to me. New CEO, no more personal aircraft. Bam. Get it and any terms they want in writing. A decent letter of indemnity, liability insurance that matches the company auto policy and makes them named insured should address the concrete concerns. The emotional concerns can be harder to address.
They can be expensive to keep up. I do most of my own maintenance, but for a single, these are pretty complex airplanes. I spent 3x the time on the K that I spent on the E. More "stuff" makes more stuff to maintain. My E was cheap to own, my K not so much. If you are looking at putting 300 hours a year on it, it will consume time and money.
And, 160 kts average on 10 gph average on an average 3-hour leg? Not gonna happen. For me, flight in the mid teens, first hour is 17 gals climbing to 15,000 at 120 indicated. Following hours at 12 gph (average) 165kts TAS cruise @ 15,000. A little less fuel if it's below ISA. Mine's a couple knots slow due to the TKS install.
For years my normal trip was Western OR to the N Cal, about 430 nm. For that, I bought an E and never regretted it. Cheap to buy, cheap to keep, honest 150 kts, and 10.5 gph block to block. If it wasn't for 10,000 FT MEAs I might still have it.