rdv,
To answer your original question - It depends... I use the following mixture settings for best performance, but with much consideration going to engine health and economy. I cut and pasted this from my response to an older conversation I had elsewhere...
Taxi - Lean to roughness and increase until smooth - I also cycle the prop and check the mags in this configuration... I seldom use a "run up" RPM to make these checks unless I have a pilot (read CFI) in the plane that would be both uncomfortable with it or unable to accept the logic of doing it that way. I want everyone to be comfy and confident, so I'll sacrifice my prop leading edges to avoid having a cockpit confrentaion.
Take off - Normaly full rich* If DA is ≥ 3000ft then I lean to target EGT on the richest cylinder which is about 1275-1300 on my plane or about 225-250 ROP...
Climb - Target EGT, see above... it just takes a slight twist about every 1000ft to keep richest cylinder's EGT ≤ 1300df.
Cruise - DAs of 150ft (low down the coast or river running) to 7500ft I'm LOP... I run ~55-65 Df LOP when down on the deck in level flight (maintaining CHT of <~370 on hot summer days and <~350 in the winter). Degrees from peak on the lean side will decrease as cruise DA increases. At 3000 I'm 35-40LOP working towards peak as I climb (which I usually get to around 7500-8500 DA) but holding CHTs in the earlier defined area. As I get into higher altitude ops, the surplus of air available for reasonable power settings LOP becomes an issue, so I often cruise at peak or around ~5df LOP in the 7000 - 9000 DA range. Higher than 10K and I run ROP as close to 75ROP as possible with CHTs in mind.
[As an aside, I was very surprised at the speeds my old stock F was able to attain at DAs in the low 16,000s at 75ROP...]
Descent - I often maintain WOT ram air on and lean to reduce power. Normal descents are at 500-1000fpm. As I get within a few thousand feet of TPA I enrichen to target take off EGT-50 and leave it that way until touchdown...from that point on I typically use the throttle for power changes. The final lean to take off EGT mentioned above puts the mixture perfect for a full power go around in the rare case that it is needed, regardless of whether I'm landing at a 700ft or a 7000ft DA...
That is all...
Edit - Every few flights or so I will do a high power LOP mag check in descent to verify the health of my ignition system; it will show a problem long before the typical 1700rpm, full rich, ground run up will; it's a more strenuous test of the ignition systems capabilities... Bad plugs will sometimes only reveal themselves at high cylinder pressures and an inflight check will show it every time...
I know this all might read terribly complicated, but it's actually pretty simple in practice.