If you fly at altitudes that need O2, it would be a GOOD idea to do an altitude ride. I think the FAA still does them, but you have to go to OKC to do them.
Each person has their own hypoxia symptoms and tolerance. And, as has been mentioned, it can change from day to day.
I did my chamber rides in the USAF. When we did the hypoxia demo, I outlasted the patience of the instructors. I was going well, not great, but functioning for over 5 minutes, maybe 10. They gave up.
Years later I was flying with a couple of friends, both pilots. I was left seat as CFII/Safety pilot. Right seat was under the hood. We were VFR (IFR current, but without current charts) and had to climb to 13.5 for weather (less than 30 minutes) I noticed the guy under the hood stat bobbing around. I looked back, and the guy in the back was OUT. I was fine.