Speed: groundspeed is determined much more by winds aloft than anything I do with the engine, unless I slow it down for some reason. And I never slow down unless I'm going to land.
Fuel consumption: Using MP to determine ff LOP kind of takes this variable out of the mix. In cruise down low using the throttle to keep MP in the range of 22-24" I'll run the richest cyl. about 15-20 degrees LOP. Up higher WOT I'll run at peak EGT. Using this method, my cruise CHT's max out at 300-340 this time of year, 340-370 in the summer. Down low I get 8.5 < ff < 9.2, when 22" < MP < 24". When MP< 22 WOT, I see ff in the 8.3 to 7.8 range from about 7k to 11.5k cruising altitude.
Fuel efficiency: see speed.
Longevity: yes, that is a concern. I'd like to be as gentle as possible on the engine while cruising at a decent IAS for a given altitude.
So- given my means of setting the engine: ff=f(MP), what is the "best" rpm to use? My hunch is that it is the higher one flies, more rpms are optimal, particularly after you go to WOT and no longer control the MP. Various articles I've read mention that it is better to use higher prop speed flying higher because of reduced air density. But how many rpms? 2550? 2600? Higher engine speed means higher power and higher pumping losses, which are probably minor, and maybe a bit higher engine wear.
Realizing that I'm talking about sensible operation and a second order effect in a portion of the performance curves where the response surface is pretty flat- maybe it just doesn't matter as @PT20J wrote that Bob Kromer suggests. Maybe I just optimize for smoothest ops, which tends to be about 2500 rpm. I guess we can consider my question answered unless someone else can offer some reason to run at a different prop speed above 7000 ft.