I have a good, long history with angle valve cylinders as an A+P and pilot/owner.
A quick story: BPA built us a wonderful, high compression, ported, and modified angle valve engine for our "experimental exhibtion" Extra 300L. 4 of the 6 brand new cylinders failed at 90 hours, with compressions in the 50's and 30's. Being a bit annoyed with Lycoming's quality control, I personally overhauled the cylinders. Over time, I came to the conclusion that the cylinders actually failed due to localized bore overheating and that "new" is no assurance of reliable performance. Air cooled engines really are a different animal, with uneven, localized cooling.
I clearly understand your reluctance to play the musical cylinder game. Certainly, you could install 4 new units, and "if" they are problem free at overhaul time, simply overhaul the cylinders. They won't have many cycles on them (like you might find with OH-exc cyls) , and they won't be at additional risk of early failure (vs. new) .
However, if, you have a known good cylinder, with a simple problem (leaking valve, for example) I believe it's worth considering a simple IRAN (inspect and repair as necessary). Not only does it cost far less, but when done properly, it's as reliable as any other option. The exception would be high time units that have known weld repairs.
It is not uncommon for new cylinders make several hundred hours, only to lose compression, then be IRAN'd and make overhaul with ease!