Thanks to all for the responses! And by all means, readers feel free to keep them coming.
Mission: mostly long distances (>300NM, and often much farther than that). I anticipate crossing the Rockies frequently. A lot of night flying. I will almost never have more than one passenger, though I would like to lay flat the right seats to create a make-shift bed for the wife (assuming it's possible).
What draws me to the F is that the Rajay is manually controlled, so no need to have it wear when I'm down low. It's also manual gear and the benefits of that should be obvious (though not all will consider them benefits per se). And not dealing with the 231 engine and 1800 TBO are attractive.
But the 231 is a lot newer. And my understanding is that it's a bit larger than the F. Further, as Carusoam importantly notes, it's a known quantity given how much more common they are. And the ability to upgrade to the -MB engine for 252-esque performance is nice too.