I’m having the same problem with my 3rd cylinder. I’m breaking in the new engine so I’ve been skeptical if that spread (40-50 degrees on the CHT) might be an issue. But from time to time i have the misfiring/detonating sound which is concerning that there could be a problem. So far we have checked compressions twice, the injector lines, injector valves, cleaned the spark plugs, checked to make sure sparks are adequate, swapped spark plugs on cylinders, replaced fuel divider, checked induction tube, and even checked the mag and the mag timing today and still haven’t found the problem. Not sure if pulling data from my JPI monitor would give me any additional info since engine is about 20 hrs old. Wondering if anyone has had anything similar to this in the past.