Newbie here - I usually read and learn, but can't pass on the chance to put in a plug for my favorite place in the Southeast...
If you and the wife are open to something a little rustic and out of the way, check out the Big South Fork National River and Recreation Area https://www.nps.gov/biso/index.htm. Fly into KSCX (Scott County Airport) which has an Airpark - The Big South Fork Airpark https://www.bsfairpark.com/ The Big South Fork National River and Recreation Area is nearby and has cabins available via private owners , or I think that the Air Park has a guest house. Crossville TN nearby has the Cumberland County Playhouse to satisfy any cultural urges (not certain of the schedule...). There is also a nice BnB in an area called "Historic Rugby". AirNav lists courtesy transportation as being available, I am not certain of Rental Car availability, but I bet the folks running the Airpark would be accommodating and helpful in that regard.
I grew up in the area and it is stunningly beautiful in the Park.
(Future M20 J/K owner)